Role of Ondansetron in Spinal Anaesthesia Induced Hypotension (NCT06727201) | Clinical Trial Compass
Not Yet RecruitingPhase 2/3
Role of Ondansetron in Spinal Anaesthesia Induced Hypotension
Egypt160 participantsStarted 2025-01-01
Plain-language summary
The objective of this study is to determine the effect of ondansetron on the total consumption of norepinephrine infusion needed to prevent spinal anaesthesia induced hypotension in cesarean section.
Who can participate
Age range19 Years ā 40 Years
SexFEMALE
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Inclusion Criteria:
* Age from 19 to 40 years old.
* Singleton pregnancies with a gestational age of at least 37 weeks.
* pregnant women are scheduled for elective caesarean delivery.
* Patients with stable vital signs.
* Patients with normal laboratory investigations.
* patients undergoing spinal anaesthesia for caesarean delivery via Pfannenstiel incision with exteriorizaion of the uterus.
Exclusion Criteria:
* Patient's refusal.
* Age \< 19 or \> 40 years.
* Height\<150 cm, weight \< 60 kg, body mass index (BMI) ā„40 kg/m2.
* Contraindications to spinal anaesthesia (Coagulopathy, increased intracranial pressure, or local skin infection).
* Patients with cardiac morbidities.
* hypertensive disorders of pregnancy as pre-eclampsia.
* peripartum bleeding.
* Patients with respiratory morbidities.
* Convulsions.
* Bleeding diathesis.
* Known allergy to any drugs used in this study.
What they're measuring
1
Total consumption of norepinephrine during the whole surgical procedure.
Timeframe: Just after subarachnoid block till the end of surgery