The purpose of this study is to evaluate a pandemic flu H5 strain messenger ribonucleic acid (mRNA) vaccine at 3 dose levels (low, medium, and high) in comparison with placebo in 276 healthy adult participants to select the adequate dose for further clinical development. The duration per participant will be approximately 13 months.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Presence of immediate adverse events (AEs) within 30 minutes after each/any injection
Timeframe: Within 30 minutes of any/each injections
Presence of solicited injection site reactions through 7 days after each/any injection
Timeframe: Through 7 days after each/any injections
Presence of solicited systemic site reactions through 7 days after each/any injection
Timeframe: Through 7 days after each/any injections
Presence of unsolicited AEs through 21 days after the first injection and through 28 days after the second injection
Timeframe: Through 21 days after the first injection and through 28 days after the second injection
Presence of medically attended adverse events (MAAEs) through 180 days after the last injection
Timeframe: Through 180 days after the last injection
Presence of adverse events of special interest (AESIs) throughout the study
Timeframe: Throughout the study, approximately 13 months
Presence of serious adverse events (SAEs) throughout the study
Timeframe: Throughout the study, approximately 13 months
Presence of out-of-range biological test results (including shift from baseline values) through a maximum of 8 days after each injection
Timeframe: Through a maximum of 8 days after each injection