Effect of Different Root Canal Sealers on Postoperative Pain (NCT06726837) | Clinical Trial Compass
CompletedNot Applicable
Effect of Different Root Canal Sealers on Postoperative Pain
Turkey (Türkiye)72 participantsStarted 2024-12-13
Plain-language summary
This randomized clinical trial aimed to evaluate postoperative pain following the use of bioceramic and epoxy resin-based root canal sealers in combination with the continuous wave of condensation technique (CWCT), addressing a clinically relevant gap in the literature.
Seventy-two patients with single-rooted teeth diagnosed with asymptomatic irreversible pulpitis and presenting without preoperative pain were randomly assigned to three groups according to the root canal sealer used. The teeth were treated using AH Plus, TotalFill BC, or Bio-C Sealer. All endodontic procedures, including post-endodontic restorations, were completed in a single visit using the continuous wave of condensation technique (CWCT), following standardized preparation and irrigation protocols.
Patients were provided with a Visual Analog Scale (VAS) form and were instructed to record their pain intensity on a scale from 0 to 10 at 6, 24, 48, and 72 hours, and 7 days after root canal treatment. Patients were recalled on day 7, and the completed VAS forms were collected.
The null hypothesis was that the type of root canal sealer would have no statistically significant effect on postoperative pain levels. The alternative hypothesis was that, regardless of sealer type, the incidence and severity of postoperative pain would be significantly higher within the first 24 hours following treatment compared with the other assessment time points.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients aged 18-65 years
* Patients who agreed to participate in this study
* Patients with single-rooted, single-canal maxillary or mandibular teeth diagnosed with asymptomatic irreversible pulpitis
* Patients with asymptomatic teeth
* Patients who have not used any analgesic, anti-inflammatory, or antibiotic drugs in the last 7 days
* Patients with good oral hygiene
* Patients with a sustained positive response to cold test and electric pulp test
* Patients with healthy periapical tissues (to be confirmed by periapical radiography)
Exclusion Criteria:
* Patients who refused to participate in this study
* Patients with medical problems (patients with immunosuppressive/systemic diseases, patients on medication)
* Patients with negative responses to thermal and electrical pulp tests
* Patients with advanced periodontal disease (probing depth \>4 mm)
* Patients with preoperative percussion and palpation of the involved tooth
* Open apex, presence of calcification, presence of resorption
* Patients requiring endodontic treatment of more than one tooth
* Patients with allergic sensitivity to materials and agents to be used during root canal treatment
* Patients with allergic sensitivity to local anesthetics
* Patients with systemic or allergic sensitivity to NSAIDs
* Pregnant and lactating patients
* Teeth that cannot be restored due to excessive material loss in the coronal structure
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.