Quantitative Margin Assessment Using High-resolution Positron Emission Tomography - Computed Tomograhy

Inclusion Criteria: * Age ≥18 years. * Patient is confirmed with oral squamous cell carcinoma, soft tissue sarcoma or osteosarcoma. * Patient is indicated to undergo curative surgery of the primary tumor. * Patient is estimated compliant for study participation by the investigator. * Written informed consent. Exclusion Criteria: * Medical or psychiatric conditions that compromise the patient's ability to give informed consent; * Patient has previously received radiotherapy of the primary tumor region; * Patient has participated in other clinical studies with radiation exposure of more than 1 mSv in the past 12 months; * A blood glucose level over 200 mg/dL on the day of surgery. * Pregnancy or lactation.