The purpose of the study is to investigate the safety, tolerability, and pharmacokinetic parameters of 2 dose strengths of donzakimig, each administered subcutaneously as a single dose, in healthy Chinese and Japanese study participants.
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Occurrence of treatment-emergent adverse events (TEAEs)
Timeframe: From Baseline to End of Study visit (up to Day 57)
Occurrence of serious treatment-emergent adverse events (serious TEAEs)
Timeframe: From Baseline to End of Study visit (up to Day 57)
Maximum plasma concentration (Cmax) of donzakimig
Timeframe: Sampling timepoints will be on Day 1 (D1): at predose and 6 hours (h), 24h (D2), 72h (D4), 120h (D6), D8, D15, D22, D36, and D57 after investigational medicinal product (IMP) administration.
Area under the plasma concentration-time curve from time 0 to t of donzakimig
Timeframe: Sampling timepoints will be on Day 1 (D1): at predose and 6 hours (h), 24h (D2), 72h (D4), 120h (D6), D8, D15, D22, D36, and D57 after investigational medicinal product (IMP) administration.
Area under the plasma concentration-time curve from zero to infinity of donzakimig
Timeframe: Sampling timepoints will be on Day 1 (D1): at predose and 6 hours (h), 24h (D2), 72h (D4), 120h (D6), D8, D15, D22, D36, and D57 after investigational medicinal product (IMP) administration.