Scrotal Surgery After Laparoscopic Donor Nephrectomy (NCT06716723) | Clinical Trial Compass
CompletedNot Applicable
Scrotal Surgery After Laparoscopic Donor Nephrectomy
Canada9,878 participantsStarted 2002-04-01
Plain-language summary
This study will examine whether laparoscopic nephrectomy is associated with a higher long-term risk of receiving scrotal surgery in male living kidney donors compared to male nondonors from the general population who have similar baseline health indicators. Both groups will be followed for many years.
Who can participate
Age range18 Years – 106 Years
SexMALE
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\* Donors \*
Inclusion criteria:
\- Male persons who received a laparoscopic nephrectomy in Ontario, Canada between April 1, 2002, and March 31, 2023 are eligible to enter the study.
Exclusion criteria:
* Any person with data errors in their database records (such as missing or invalid age; they expect to exclude very few persons for these reasons). Data errors also include evidence of prior dialysis or a prior solid organ transplant, as such persons are not eligible to become a donor.
* Any person who was not a permanent Ontario resident (i.e., they live outside of Ontario, and only came to Ontario to donate a kidney to their intended recipient). This will include anyone who is not eligible for the Ontario Health Insurance Plan, anyone whose date of last contact in the databases is less than 4 months after the cohort entry date, and any person without a physician visit in the last 1-year.
* Any person who is \<18 years of age on the date of nephrectomy (as only under exceptional circumstances should a person less than 18 be approved for living donation).
* Any person who, before donation, received a scrotal ultrasound or a scrotal procedure other than a vasectomy.
* Non-donors \*
Inclusion, exclusion and selection criteria:
* Before nephrectomy, living donors undergo rigorous health screening. The investigators will select a similarly healthy segment of the general population using restriction and matching.
* The investigators will randomly assign a cohort-entry dat…
What they're measuring
1
Scrotal Surgery
Timeframe: Donors and their matched non-donors will enter the cohort between April 1, 2002 and March 31, 2023, and will be followed until study outcome (first event), death, emigration from the province, or the end of the observation period (March 31, 2024).
Trial details
NCT IDNCT06716723
SponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's