RecruitingNot Applicable

PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure. The PREVISION Study

Canada80 participantsStarted 2025-01-27

Plain-language summary

The goal of this observational study is to assess the potential non-invasive tools (e.g. regional ventilation, respiratory muscle response, lung mechanic's parameters) to identify the risk of failure when using high flow nasal cannula (HFNC) or non-invasive ventilation (NIV). The main question, it aims to answer is: Does abnormal regional ventilation could predict HFNC or NIV failure?

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age of ≥ 18 years * Using NIV or HFNC anywhere in the hospital Exclusion Criteria: * Chronic CO2 retention * Neuromuscular disorder * Requiring home NIV (CPAP or BIPAP) * Tracheostomy * Contraindication to EIT placement: pacemaker/defibrillator implantation, burns at the area of EIT placement

What they're measuring

Difference in regional ventilation distribution (%)

Timeframe: The parameter is measured at the time of enrolment. Failure of HFNC or NIV is adjudicated at 7 days.

Trial details

NCT IDNCT06716463

SponsorUnity Health Toronto

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-06

View on ClinicalTrials.gov More Ventilatory Failure trials