The objective of this observational study was to gain a deeper understanding of the epidemiology of the disease in Hungary through a broad analysis of patients with new-onset esophageal-oesophageal-stomach junction tumors, and to identify key parameters that could potentially influence the outcome of the disease and are closely correlated with morbidity and mortality. The investigators' primary objective is to identify potential factors and conditions that could be influenced and modified to enhance the disease outcome. Main questions: 1. What are the measurable changes in performance, workload, nutritional status, cardiac function, mental status in the patients studied? 2. What is the time course of the changes during and after treatment? 3. Which pathological parameters are associated with disease outcome and which are potential points of intervention to improve the course of the disease? Patients will undergo a detailed physical and nutritional assessment, non-invasive imaging tests and several questionnaires in addition to the usual pre- and post-operative examinations.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Changes in cardiac function: cardiac MR scan
Timeframe: From enrollment to the 12th postoperative month
Changes in coronary status: coronary CT scan
Timeframe: From enrollment to the 12th postoperative month
Morbidity (early and long term) classified after Clavien-Dindo.
Timeframe: 30 days (until 31st postoperative day)
Early and late mortality
Timeframe: 90 days (until 91st postoperative day)
Length of hospital stay
Timeframe: within 45 days
Number of days spent on ICU (Intensive care unit)
Timeframe: within 45 days postoperative
Changes in physical performance: 6-minute walk test (6MWT)
Timeframe: From enrollment to the 12th postoperative month
Changes in physical performance: hand grip strength test
Timeframe: From enrollment to the 12th postoperative month
Changes in physical performance: time up and go test
Timeframe: From enrollment to the 12th postoperative month
Changes in ECOG (Eastern Cooperative Oncology Group) performance status
Timeframe: From enrollment to the 12th postoperative month
Change in nutritional status, risk of malnutrition and nutritional ability: MUST (Malnutrition Universal Screening Tool)
Timeframe: From enrollment to the 12th postoperative month
Change in nutritional status, risk of malnutrition and nutritional ability: NRS (nutritional risk score)
Timeframe: From enrollment to the 12th postoperative month
Change in nutritional status, risk of malnutrition and nutritional ability Description: PG-SGA (Patient-Generated Subjective Global Assessment)score
Timeframe: From enrollment to the 12th postoperative month
Change in nutritional status, risk of malnutrition: Bioimpedance examination
Timeframe: From enrollment to the 12th postoperative month
Change in nutritional ability: swallowing test
Timeframe: From enrollment to the 12th postoperative month
Change in nutritional status: myostatin level
Timeframe: From enrollment to the 12th postoperative month
Change in nutritional status: IGF-1 level
Timeframe: From enrollment to the 12th postoperative month
Change in nutritional status: GDF-15 level
Timeframe: From enrollment to the 12th postoperative month
Change in nutritional status: IL-6 level
Timeframe: From enrollment to the 12th postoperative month