Bacterial Decolonization Plus Intraoperative Angiography for Soft Tissue Sarcomas Receiving Preop… (NCT06712433) | Clinical Trial Compass
Not Yet RecruitingPhase 2
Bacterial Decolonization Plus Intraoperative Angiography for Soft Tissue Sarcomas Receiving Preoperative Radiotherapy (CONCERTO)
United States31 participantsStarted 2026-09-30
Plain-language summary
This trial will investigate the combination of two low-cost, non-toxic strategies to assess whether they can reduce the risk of acute major wound complications in soft tissue sarcoma of the lower extremity. Intranasal mupirocin ointment twice daily and chlorhexidine body cleanser once daily for 5 days prior to radiation therapy and repeated for 5 days every 2 weeks during radiation therapy may significantly reduce the risk of acute radiation dermatitis. That, along with use of indocyanine green (ICG) angiography at the time of wound closure.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-2
✓. Newly diagnosed soft tissue sarcoma arising from the lower extremity (defined as the tumor center arising at the level of the iliac crest or below)
✓. Eligible for wide local excision
✓. Eligible for external beam radiation therapy
✓. Negative serum pregnancy test for women of childbearing potential \< 28 days prior to RT.
✓. Informed consent signed and dated to participate in the study.
✓. Willingness and ability to comply
Exclusion criteria
✕. Allergy to mupirocin and/or chlorhexidine
✕. Active dermatologic condition in RT field
✕. Tumor size \> 32cm
✕
What they're measuring
1
Incidence and type of acute major wound complications
✕. Concurrent/prior invasive malignancy that could potentially interfere with proposed treatment. Individual cases can be discussed with PI prior to registration