Post-registration Trial of the Non-immunogenic Staphylokinase in Acute Ischemic Stroke (FORPI Registry)

Inclusion Criteria: * Men and women aged 18 years and older. * Verified diagnosis of acute ischemic stroke. * The time from the symptoms onset is no more than 4.5 hours. * Thrombolysis with the non-immunogenic staphylokinase, 10 mg as a single intravenous bolus. Exclusion Criteria: * The time from the symptoms onset is more than 4.5 hours or the time of the symptoms onset is unknown. * Increased sensitivity to the non-immunogenic staphylokinase. * Systolic blood pressure above 185 mm Hg or diastolic blood pressure above 110 mm Hg or the need in the drug administration to reduce blood pressure to these levels. * Neuroimaging (CT, MRI) signs of intracranial hemorrhage, brain tumors, arteriovenous malformation, brain abscess, aneurysm of cerebral vessels. * Surgery on the brain or spinal cord. * Suspicion of subarachnoid hemorrhage. * Signs of severe stroke: clinical signs (stroke scale NIH \> 25), neuroimaging (according to CT of the brain and / or MRI of the brain in the DWI, the ischemia focuses on the territory of more than 1/3 of the CMA pool). * Simultaneous reception of oral anticoagulants, for example, warfarin with INR\> 1.3. * The use of direct anticoagulants (heparin, heparinoids) in the preceding stroke of 48 h with APTT values above the norm. * Prior stroke or severe head injury within 3 months. * Significant regression of neurological symptoms during the observation of the patient before thrombolysis. * Hemorrhagic stroke or stroke, unspecified in history. * Str…