The proposed pilot study aims to assess the underlying mechanisms of the MBI on IBS pain and the feasibility of using novel technology in the outcome measurements. The specific aims of this pilot mechanistic clinical trial are to: 1. . identify the mechanisms underlying the impact of MBI on IBS-related pain, stress responses, quantitative pain sensitivity, and gut microbiome profiles. 2. . evaluate the technological feasibility of using a wearable abdominal sensor belt and smartwatch system in measuring MBI impacts on pain in home settings. Researchers will conduct a one-arm pre- and post-music intervention among patients with Irritable Bowel Syndrome, collect the IBS pain mechanistic biobehavioral markers, and analyze the underlying pathways of the music analgesic effect. Participants will be asked to: 1. . engage in a 4-week intervention of 20 minutes, both during the day and at night, for at least five days per week. 2. . have two one-hour lab visits
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IBS visceral pain index
Timeframe: From intervention enrollment to the end of treatment at 4 weeks
Real-time self-reported pain
Timeframe: From intervention enrollment to the end of treatment at 4 weeks
Brief Pain Inventory
Timeframe: through study completion, an average of 1 year
Pain sensitivity
Timeframe: through study completion, an average of 1 year
IBS-quality of life (IBS-QOL)
Timeframe: through study completion, an average of 1 year
16S rRNA Gene-based Analysis of Gut Microbiota
Timeframe: through study completion, an average of 1 year