NT-NOA - Novel Treatment of Some Men With Non-Obstructive Azoospermia

Inclusion Criteria: * Infertile men ≥ 18 years and \< 60 years of age with azoospermia with normal semen volume (\> 0.9 mL) verified by minimum 2 semen samples. * No identifiable cause of obstruction. * Testis size (Prader Orchidometer) ≤ 15 mL on both sides in patients where no prior TESE is available * Serum AMH levels ≥5 pmol/L. Exclusion Criteria: * Chronic diseases, defined as diagnosis where signs, symptoms, and treatment imply an expected long duration and lack of a cure, such as diabetes mellitus, metabolism disorders, osteoporosis, colitis, etc. * Chromosome anomalies e.g. Klinefelter Syndrome, XX male * AZFa/b/c microdeletions besides b2/b3 og gr/gr * Detected CFTR mutation * Men with current or previous malignancies, or at potential risk of testicular cancer after baseline examination and ultrasound will be excluded * Men with hypocalcemia at baseline, defined as albumin corrected calcium \< 2.17 mmol/L or total calcium \< 2.14 mmol/L * Serum vitamin D (25OHD) levels \< 25 nmol/L * estimated Glomerular Filtration Rate (eGFR) \< 60 mL/min/1,73 m2 * Insufficient dental status * Hypersensitivity to latex, Denosumab, or to any of the excipients (acetic acid, sodium hydroxide, Sorbitol (E420), Polysorbate 20) will be excluded. * Serum Inhibin B \< 5 pg/mL * Androgen replacement therapy * Hypogonadotropic hypogonadism * BMI ≥ 35 kg/m2