Safety and Efficacy of Remote Ischemic Conditioning in Patients with Chronic Internal Carotid Artery Occlusion Receiving Hybird Surgery: a Pilot, Randomized Controlled Trial

Inclusion Criteria: * Age≥18 years, regardless of sex * Patients with chronic carotid artery occlusion who are going to undergo hybird surgery * Can cooperate with and complete brain magnetic resonance imaging (MRI) examination * Signed and dated informed consent is obtained Exclusion Criteria: * Hemorrhagic stroke * Severe cardiac dysfunction or arrhythmia * Uncontrolled hypertension (defined as systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 110 mmHg, despite medication taken at enrollment) * Severe hepatic and renal dysfunction (defined as aspartate aminotransferase (AST) or alanine aminotransferase (ALT) ≥3 times higher than the upper limit of the normal range, creatinine \>265umol/l (3mg/dl)) * The patients who have the contraindication of remote ischemic conditioning treatment, such as severe soft tissue injury, fracture or vascular injury in the upper limb. Acute or subacute venous thrombosis, arterial occlusive disease, subclavian steal syndrome, etc. * Pregnant or lactating women * He/She is participating in other clinical research or has participated in other clinical research or has participated in this study within 3 months prior to admission * Other conditions that the researchers think are not suitable for the group