A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of ALG-097558 in Subjects With … (NCT06698549) | Clinical Trial Compass
CompletedPhase 1
A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of ALG-097558 in Subjects With Renal Impairment and in Healthy Subjects With Normal Renal Function
United States12 participantsStarted 2025-02-01
Plain-language summary
This is a Phase 1 non-randomized, open-label, multiple dose, parallel-group study of ALG-097558 in subjects with severe renal impairment and subjects without renal impairment, matched for age, body weight and, to the extent possible, for gender. The primary purpose of this study is to characterize the effect of renal impairment on the plasma pharmacokinetics of ALG-097558 following administration of multiple, twice daily (Q12H) oral (PO) doses.
Who can participate
Age range18 Years – 75 Years
SexALL
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Inclusion criteria
✓. Male and Female between 18 and 75 years old
✓. Body Mass Index (BMI) 17.5 to 40.0 kg/m\^2 and a total body weight \>50 kg (110 lb)
✓. Female subjects must either be not of childbearing potential or if they are a woman of childbearing potential, they are only eligible if they and any non-sterile, male sexual partners agree to use highly effective contraceptive therapy
✓. Good general health as defined by no clinically relevant abnormalities identified by Medical History and a vital signs, clinical laboratory and 12-lead electrocardiogram (ECG) assessment
✓. Subjects must fit the demographic-matching criteria including body weight, age, and to the extent possible, gender
✓. Normal renal function (estimated Glomerular Filtration Rate \[eGFR\] ≥90 mL/min) with no known or suspected renal impairment
✓. Subject satisfies the eGFR criteria for renal impairment classification within 28 days of study drug administration
✓. Any form of renal impairment except acute nephritic syndrome (subjects with history of previous nephritic syndrome but in remission can be included).
Exclusion criteria
✕. Subjects with any current or previous illness that, in the opinion of the Investigator, might confound the results of the study or pose an additional risk in administering study drug to the subject or that could prevent, limit, or confound the protocol specified assessments or study results and interpretation
. Subjects with a past history of cardiac arrhythmias, risk factors for Torsade de Pointes syndrome (e.g., hypokalemia, family history of long QT Syndrome) or history or clinical evidence at screening of significant (subjects with normal renal function) or unstable (subjects with renal impairment) cardiac disease etc.
✕. Subjects with a history of clinically significant drug allergy
✕. Subjects with a recent (within 1 year of randomization) history or current evidence of drug abuse or recreational drug use
✕. Excessive use of alcohol defined as regular consumption of ≥14 units/ week for women and ≥21 units/week for men
✕. Unwilling to abstain from alcohol use for 48 hours prior to start of the study through end of study follow up
✕. Subjects with Hepatitis A, B, C, E or HIV-1/HIV-2 infection or acute infections such as SARS- CoV-2 infection
✕. Subjects with alanine aminotransferase (ALT) or aspartate aminotransferase (AST) values \>2x upper limit of normal (ULN)