A study to investigate the pharmacokinetics, safety, and tolerability of AZD4144 in participants with severe renal impairment, end-stage kidney disease, and in healthy participants.
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Observed maximum plasma concentration (Cmax)
Timeframe: From Day 1 to Day 14
Area under the plasma concentration-time curve from time zero extrapolated to infinity (AUCinf)
Timeframe: From Day 1 to Day 14
Area under the plasma concentration-time curve from time zero to time of last quantifiable concentration (AUClast)
Timeframe: From Day 1 to Day 14
Apparent total body clearance (CL/F)
Timeframe: From Day 1 to Day 14
Non-renal clearance of drug from plasma (CLNR/F)
Timeframe: From Day 1 to Day 14
Apparent volume of distribution based on the terminal phase (Vz/F)
Timeframe: From Day 1 to Day 14
Terminal elimination half-life (t½λz)
Timeframe: From Day 1 to Day 14
Renal clearance of drug from plasma (CLR)
Timeframe: From Day 1 to Day 4
Amount excreted (Ae)
Timeframe: From Day 1 to Day 4
Percentage of dose excreted unchanged in urine (fe)
Timeframe: From Day 1 to Day 4
Number of Treatment Emergent Adverse Events (TEAEs)
Timeframe: From Day 1 to Follow-up (Day 14/28)