This multicenter observational study aims to validate the IOTA Simple Rules, Benign Descriptors, and ADNEX model in a cohort of patients equal or under the age of 20. Moreover, the study aims to evaluate the diagnostic accuracy of subjective assessment by ultrasound and to analyze the rate of complications in patients treated conservatively.
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Estimation of the ability of the ADNEX model without CA125 to discriminate between benign and malignant adnexal masses when detected in patients aged 20 or under (AUC)
Timeframe: Outcome based on histology for group 1 assessed at 12 months after recruitment or no sign of malignancy during the ultrasound follow-up for group 2 assessed up to 12 months after recruitment.
Estimation of the ability of the ADNEX model and subjective assessment to classify adnexal masses as benign or malignant when detected in patients aged 20 or under (Sensitivity, Specificity, positive predictive value, and negative predictive value)
Timeframe: Outcome based on histology for group 1 or follow-up for group 2 (maximum 12 months after recruitment)
Estimation of the ability of the ADNEX model to predict individual risk of malignancy of adnexal masses when detected in patients aged 20 or under (Calibration)
Timeframe: Outcome based on histology for group 1 or follow-up for group 2 (maximum 12 months after recruitment)
Estimation of the ability of the Benign Descriptors to detect malignancies in patients aged 20 or under.
Timeframe: Outcome based on histology for group 1 or follow-up for group 2 (maximum 12 months after recruitment)
Estimation of the ability of the ADNEX model without CA125 to discriminate between benign and malignant adnexal masses when detected in patients aged 20 or under (AUC)
Timeframe: Outcome based on histology for group 1 or follow-up for group 2 (maximum 12 months after recruitment)