Emergency Total ECLS vs Standard ACLS With ECMO Bailout for Survival in Refractory OHCA (NCT06692075) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Emergency Total ECLS vs Standard ACLS With ECMO Bailout for Survival in Refractory OHCA
Taiwan332 participantsStarted 2024-11-01
Plain-language summary
The goal of the clinical trial is to learn if early extracorporeal life support ( ECLS ) will save more out-of-hospital cardiac arrest ( OHCA ) patients with good neurological outcome. It will also learn if emergency ECLS is safe in the OHCA rescue. Researchers aim to investigate if emergency total ECLS is better than standard advanced cardiac life support ( ACLS ) first, followed by bailout ECMO if required, for survival with favorable neurological outcome in OHCA patients. Participants meeting criteria of OHCA with witness, bystander CPR, shockable initial rhythm with repeated defibrillation, and transport time less than 30 min will be compared between total ECLS versus standard ACLS first with bailout ECMO protocols. All participants will receive emergency interventional coronary revascularization , intensive care unit therapy , cardiac ward care and up to 180 days of clinical follow up after survival .
Who can participate
Age range18 Years – 75 Years
SexALL
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Inclusion criteria
✓. adults aged 18-75 years old
✓. witnessed cardiac arrest with bystander CPR
✓. initial shockable rhythm as ventricular fibrillation or pulseless ventricular tachycardia ( VF/pVT )
✓. repeated defibrillation shocks ( more than 2 ) by external defibrillator
✓. estimated transportation time from 119 call to arrival at emergency service less than 30 minutes.
Exclusion criteria
✕. age less than 18 years or more than 75 years old
✕. non-shockable initial rhythm, i.e. pulseless electrical activity or asystole
✕. acute aortic dissection
✕. acute massive pulmonary embolism
✕. intracerebral hemorrhage
✕
What they're measuring
1
The rate of survival with favorable neurological outcome ( modified Rankin score less than 3 or cerebral performance category scale 1 or 2 ) at 30 days after discharge from hospital, in percentage
Timeframe: From randomization to 30 days after survival discharge from hospital
Trial details
NCT IDNCT06692075
SponsorTaipei Medical University Shuang Ho Hospital