Effect of Timing of Dexamethasone During Induction on Postoperative Outcomes (NCT06685991) | Clinical Trial Compass
Not Yet RecruitingPhase 4
Effect of Timing of Dexamethasone During Induction on Postoperative Outcomes
300 participantsStarted 2024-12-01
Plain-language summary
This study aims to investigate how the timing of dexamethasone administration during anesthesia induction affects patient outcomes after surgery. Dexamethasone is commonly used to reduce nausea and inflammation during and after surgery. However, it is not yet known if administering dexamethasone at different times during induction (before, during, or after specific anesthetic drugs) leads to better recovery and fewer postoperative complications.
Participants will be randomly assigned to one of three groups: one group will receive dexamethasone before fentanyl, another after the muscle relaxant, and a third group will not receive dexamethasone. This approach will help us understand if the timing of dexamethasone affects patient outcomes such as nausea, pain, and recovery quality. The study is triple-blinded, meaning that the participants, care providers, and investigators will not know which group the participants are in, to ensure unbiased results.
Who can participate
Age range
18 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 18 years or older
* Scheduled for elective non cardiac surgery requiring general anesthesia
* surgery last at least 90 minutes
* scare of more than 5 cm Able to provide informed consent Eligible for dexamethasone administration as part of routine perioperative care
Exclusion Criteria:
* Known allergy or hypersensitivity to dexamethasone or related corticosteroids
* History of uncontrolled diabetes mellitus or significant blood glucose management issues, as dexamethasone may affect glucose levels
* Severe cardiovascular instability or hemodynamic issues contraindicating study participation
* Patients receiving immunosuppressive therapy or with conditions affecting the immune system, as corticosteroids may alter immune responses
* Pregnancy or breastfeeding, due to potential risks to the fetus or infant
* Current or recent (within 30 days) use of other glucocorticoids, which may interfere with study outcomes
* Patients with psychiatric or cognitive conditions that impair their ability to consent or adhere to study protocols
* Lack of informed consent
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Incidence of Postoperative Nausea and Vomiting (PONV)