Not Yet RecruitingPhase 4

Comparative Study Between Intrathecal Magnesium Sulfate, Neostigmine and Fentanyl as Adjuvant for Bubivacaine in Postoperative Analgesia in Lower Abdominal Surgeries

66 participantsStarted 2024-12-01

Plain-language summary

Lower abdominal surgeries often result in severe pain, which in turn can cause rapid and shallow breathing, retention of secretions and poor patient compliance. Justifiably, apart from the fear for the surgery outcome, patients are concerned mainly with postoperative pain. If treated inadequately, acute pain can have serious consequences for patient health mainly with postoperative complications, prolonged recovery and increased length of hospital stay. Higher levels of postoperative pain and pain distress are associated with increased morbidity, poorer functional recovery, and reduced quality of life. Aim of the study To compare the duration, quality of analgesia, and side effects between intrathecal Magnesium sulfate, neostigmine and fentanyl as adjuvant for bubivacaine as postoperative analgesia in lower abdominal surgeries

Who can participate

Age range18 Years – 55 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * • the American Society of Anesthesiologists (ASA) classification I-II * Age \>18 up to 55 years old * Both sex * Patients who will undergo lower abdominal surgeries Exclusion Criteria: * • Patients' refusal. * Patients with morbid obesity, cardiac diseases, hepatic diseases, renal diseases, diabetes mellitus with polyneuritis. * Patients who were in risk-scoring groups American Society of Anesthesia III-IV. * Hypertensive patients receiving therapy with adrenergic receptor antagonist, calcium channel blocker and/or angiotensin converting enzyme inhibitor. * Patients with coagulation disorders, those receiving any anticoagulants. * Any history of allergy to local anesthetic or other drugs used in the study, patients on examining drugs. * Any contraindication to spinal anesthesia ( infection at puncture site and increased intracranial tension and Patients with psychiatric illness and neurologic diseases.

What they're measuring

first request of rescue analgesia

Timeframe: baseline

Trial details

NCT IDNCT06685705

SponsorAssiut University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-12-01

Contact for this trial

Mohsen Mohamed Mohsen Mahmoud, resident doctors

+101092209597 mohsen.16266366@med.aun.edu.eg