The purpose of this study is to evaluate the mass balance, metabolism, elimination, and drug levels of \[14C\]-BMS-986504 (MRTX1719) in participants with advanced solid tumors with homozygous methylthioadenosine phosphorylase deletion.
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Maximum observed concentration (Cmax)
Timeframe: Up to 2 weeks
Time of maximum observed drug concentration (Tmax)
Timeframe: Up to 2 weeks
Area under the concentration-time curve from time zero to the time of the last quantifiable concentration (AUC(0-T))
Timeframe: Up to 2 weeks
Area under the concentration-time curve from time zero extrapolated to infinite time (AUC(INF))
Timeframe: Up to 2 weeks
Terminal elimination half-life (T-HALF)
Timeframe: Up to 2 weeks
Apparent total body clearance (CLT/F)
Timeframe: Up to 2 weeks
Apparent volume of distribution during the terminal phase (Vz/F)
Timeframe: Up to 2 weeks
Percentage of estimated part for the calculation of AUC(INF) (%AUC(INF))
Timeframe: Up to 2 weeks
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Blood-to-plasma total radioactivity (TRA) ratio
Timeframe: Up to 2 weeks
Total amount of administered dose recovered in urine (UR)
Timeframe: Up to 2 weeks
Percent of administered dose recovered in urine (%UR)
Timeframe: Up to 2 weeks
Renal clearance (CLR) in urine
Timeframe: Up to 2 weeks
Total radioactivity in UR
Timeframe: Up to 2 weeks
Total radioactivity in %UR
Timeframe: Up to 2 weeks
Total radioactivity in total amount of administered dose recovered in feces (FR)
Timeframe: Up to 2 weeks
Total radioactivity in percent of administered dose recovered in feces (%FR)
Timeframe: Up to 2 weeks
Total amount of radioactivity recovered (Rtotal)
Timeframe: Up to 2 weeks
Total percent of radioactivity recovered (%TOTAL)
Timeframe: Up to 2 weeks
TRA amount recovered and fraction of the radioactive dose in vomit if applicable
Timeframe: Up to 2 weeks