Treating Lid Wiper Epitheliopathy (NCT06671041) | Clinical Trial Compass
CompletedPhase 4
Treating Lid Wiper Epitheliopathy
United States52 participantsStarted 2024-05-27
Plain-language summary
Lid wiper epitheliopathy (LWE) is a relatively new entry into the abundance of clinical ocular surface health signs. LWE was first reported in 2002 as a potential cause for dry eye disease (DED) (Korb et al., 2002). This clinical sign is visualised by everting the eyelid after a dye has been applied and observing the palpebral conjunctiva proximal to the eyelashes
Who can participate
Age range18 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults ≥18 years of age
* best corrected visual acuity (BCVA) of 20/100 or better
* who have symptomatic DED will be recruited (SPEED ≥6)
* Subjects will also be required to have a LWE score of 1.0 or greater to be included in the study.
* Subjects will be required to discontinue contact lens wear throughout the study.
Exclusion Criteria:
* known systemic health conditions that are known to alter tear film physiology (e.g., primary and secondary Sjögren's syndrome),
* have a history of ocular surgery within the past 12 months, have a history of severe ocular trauma, active ocular infection or inflammation,
* are currently using Accutane or ocular medications, or if they are pregnant or breast feeding.
* Artificial tear use will be discontinued at least one week prior to enrollment. Subjects with a condition or in a situation, which in the examiner's opinion, may put the subject at significant risk, may confound the study results, or may significantly interfere with their participation in the study will be excluded.
* Subjects that have had a physical meibomian gland treatment withing 1 month of enrollment (iLux, Lipiflow, etc.) will be excluded.
* Subjects will not be allowed to use any eye drops beyond their assignment during the study.