A Study to Evaluate the Effect of a Topical Retinol on Epigenetic Changes and Expression of Certa… (NCT06658847) | Clinical Trial Compass
CompletedNot Applicable
A Study to Evaluate the Effect of a Topical Retinol on Epigenetic Changes and Expression of Certain Genes in the Skin Using Non-invasive Measurements
United States66 participantsStarted 2024-11-07
Plain-language summary
This study is being conducted to confirm whether skin tape stripping methodology can identify changes in gene expression (i.e. whether different genes are turned on to make proteins) in aged skin after use of a retinoid.
Who can participate
Age range40 Years – 65 Years
SexFEMALE
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Inclusion criteria
✓. Has clinically determined moderate photodamage (defined as a score of 4 - 6 on a 0- 9-point scale) on the face at Visit 1.
✓. Is able to read, write, speak, and understand English.
✓. Generally in good health.
✓. Intends to complete the study and is willing and able to follow all study instructions.
Exclusion criteria
✕. Has known allergies or negative reactions to common topical skincare products, adhesives, latex, or ingredients in the study products.
✕. Has clinically active bacterial, fungi, or viral skin infection or has frequent skin infections.
✕. Presents with a skin condition that may increase risk to the subject, influence study results, or interfere with study evaluations (e.g. acne, psoriasis, eczema, atopic dermatitis, cutaneous xerosis, erythema, active skin cancer, tattoos, scarring, scratches/broken skin, sunburn, excessive hair growth, or very uneven skin tone) as determined by the principal investigator (PI).
✕. Has self-perceived sensitive skin.
✕. Is a regular (occasional to daily) smoker of cigarettes or user of electronic cigarettes (vaping pens).
✕. Is a regular (occasional or frequent) user of tanning beds and/or self-tanning products.
✕. Has had a surgical or aesthetic procedure in the last 3 months that can affect facial wrinkles or facial pigmentation (e.g. botulinum toxin (Botox) injections, chemical peels, laser-based therapies to the face, or face lift surgery).