This study is a Prospective Single Arm, dual cohort Open Label Feasibility trial to evaluate the initial safety and signal of efficacy of a novel extracorporeal blood purification (EBP) procedure in either mPDAC or mCRC refractory to systemic therapy. Site selection will be dependent upon the site's familiarity with extracorporeal blood purification platforms as well as the diagnosis and management of mPDAC and mCRC. Adults (18 years old and older, ECOG PS of equal or less than 2) with a diagnosis of either mPDAC as defined histologically (microscopically) as a "pancreatobiliary type" adenocarcinoma who experienced disease progression or not tolerating fluoropyrimidine-, oxaliplatin- and irinotecan- based regimens or prior treatment with gemcitabine and nab-paclitaxel or are not candidates for chemotherapy or mCRC patients who experienced disease progression on 5-fluorouracil (5-FU), capecitabine, oxaliplatin and irinotecan as FOLFIRI and/or FOLFOX and/or XELOX and/or XELIR and/or FOLFOXIRI/FOLFIRINOX or who are not candidates for chemotherapy with at least 5 cells/mL CTCs in peripheral blood and/or portal vein.
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Incidence of procedure-emergent adverse events (AEs) graded using the NCI CTCAE Version 5.0
Timeframe: 210 days
Incidence of procedure-emergent serious adverse events (SAEs) graded using the NCI CTCAE Version 5.0
Timeframe: 210 days
Evaluation of Survival
Timeframe: 60, 120, 180 and 210 days
Change in CTC Concentration
Timeframe: 180 days
Capacity for the ONCObind filter to remove circulating tumor cells
Timeframe: 60 days
Evaluate the Quality of Life (QOL)
Timeframe: 210 days