Innovating Shorter, All- Oral, Precised Treatment Regimen for Rifampicin Resistant Tuberculosis：BDLL Chinese Cohort

Inclusion Criteria: * Participants are willing to sign informed consent of this trial, those without capacity for civil conduct need their legal guardian to sign * Participants (and their legal guardian if applicable) are willing to cooperate to complete all trial procedures * Male or female, 12 years or older, weight ≥ 30kg * Confirmed pulmonary tuberculosis with resistance to rifampin by phenotypic or genotypic susceptibility testing within 3 months, and must be re-confirmed by sputum culture sampled at trial inclusion * Women with childbearing potential should not be pregnant, confirmed by a volunteered negative pregnancy test, and are willing to use effective contraceptive method from giving consent to 3 months after study treatment * Men with childbearing potential must be willing to use condom or other effective contraceptive methods to avoid their sex partners from being pregnant * Women in breastfeeding period must be willing to discontinue breastfeeding from giving consent to 3 months after study treatment * Participants are willing to take HIV test, and willing to take appropriate antiretroviral therapy if positive Exclusion Criteria: * Previously use of Bedaquiline or Delamanid for at least 28 days * Concomitant hematogenous disseminated tuberculosis, or severe pulmonary tuberculosis in investigator's opinion (including tuberculosis of the digestive system, osteoarticular tuberculosis or tuberculous meningitis) * Currently using any drug that has been prohibited…