A Study of Different Programs to Help ALL Patients With Taking Maintenance Medicine at Home

Inclusion Criteria: * Age: \>= 10 years and =\< 25 years * Previously enrolled onto AALL1732 * Consented to the AALL1732 mercaptopurine adherence correlative study * Maintenance therapy has not yet begun * English or Spanish-speaking (patient and parent/other adult) * Planning to receive 6MP (as tablets) during maintenance phase of therapy * Able and willing to use the MEMS® TrackCap™ (e.g., not using a pillbox or prescribed liquid 6MP) * Has a designated parent/other adult who is willing to enter into a mutual agreement with the patient to participate in a daily supervised medication administration routine * Patient/parent/other adult must be willing to use a smartphone to receive medication reminders * Receiving treatment at a Children's Oncology Group (COG) institution in the United States Exclusion Criteria: * Patients who have previously participated in or are currently participating in another intervention clinical trial designed to improve adherence * Regulatory requirements * All patients and/or their parents or legal guardians must sign a written informed consent * All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met