RecruitingPhase 1

Genicular Nerve Block After Open Reduction Internal Fixation of Tibial Plateau

United States38 participantsStarted 2024-11-01

Plain-language summary

The investigators are conducting this research study to find better ways of treating pain following knee surgery. There is a standard (accepted) approach, which involves injection of numbing medication into the area around the participant surgical incision. The investigators hope to discover if providing numbing medication to a nerve that controls pain in a larger area of the knee (a nerve block), might be better at post-operative pain control.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: • Any adult patient (ages 18 and over) undergoing open reduction internal fixation of an acute isolated tibial plateau fracture Exclusion Criteria: * Subjects younger than 18 * Polytraumatized Subjects * Subjects with pathologic fractures * Subjects with tibial plateau fractures treated nonoperatively * Subjects with tibial plateau fractures treated operatively but with re-operations at the same site * Subjects with open fractures * Subjects with fracture-dislocations * Subjects with active or history of anxiety * Subjects with visual analog scale anxiety score ≥ 7 measured preoperatively * Subjects with chronic pain syndromes * Subjects with chronic opioid use * Subjects with illicit drug use disorder * Subjects with alcohol abuse disorder * Subjects with kidney disease precluding use of ketorolac * Subjects with liver disease precluding the use of acetaminophen * Subjects with allergy to acetaminophen, non-steroidal anti-inflammatory drugs (NSAIDs), opiates or local anesthesia * Subjects with inability to provide a visual analog scale score postoperatively * Subjects with contraindications to receiving peripheral nerve blocks, including relevant neurologic deficits, active infection at sites of injections - re-operation at the same site

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Pain Ratings from Visual Analog Scale (VAS)

Timeframe: one hour, two hours, and discharge from PACU

Trial details

NCT IDNCT06639503

SponsorUniversity of Chicago

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-09-01

Contact for this trial

Anthony Christiano, MD

773-834-3531 anthony.christiano@bsd.uchicago.edu

View on ClinicalTrials.gov More Tibial Plateau Fractures trials