Window of Opportunity Study of DSP-0390 in Gliomas

Inclusion Criteria * Patients must have either newly diagnosed and suspected glioma per radiographic features, or radiographic recurrence of a histologically confirmed IDH-mutant glioma with the following grade requirements: * ARM A: suspected lower grade glioma, or histologically confirmed grade II IDH-mutant glioma OR * ARM B: suspected high grade glioma, or histologically confirmed grade III or IV glioma. * Patient must be a candidate for surgical resection * At least 18 years of age. * Karnofsky ≥ 70% * Adequate bone marrow and organ function as defined below: * Absolute neutrophil count ≥ 1.5 K/cumm (patient may not use G-CSF or GM-CSF to achieve this ANC level) * Platelets ≥ 100 K/cumm * Hemoglobin ≥ 9 g/dL (patient may not receive transfusion or use erythropoietin to obtain this Hgb level) * Total bilirubin ≤ 1.5 x IULN (or ≤ 3 x IULN for patients with known Gilbert's syndrome) * AST(SGOT)/ALT(SGPT) ≤ 3.0 x IULN * International normalized ratio (INR), prothrombin time (PT), partial thromboplastin time (PTT), or activated partial thromboplastin time (aPTT) ≤1.5 x ULN. The use of anticoagulants is permitted as long as the PT/(a)PTT is within therapeutic limits (according to the local institution standard) and the patient has been on a stable anticoagulant regimen for at least 2 weeks prior to Day 1. * Creatinine Clearance of ≥40 mL/min per Cockroft-Gault formula or by a 24 hour urine. * If a patient is using an antiepileptic medication, the patient i…