Efficacy of Intravenous Nefopam, Dexmedetomidine, and Meperidine in Preventing Post-Spinal Anesth… (NCT06627816) | Clinical Trial Compass
CompletedNot Applicable
Efficacy of Intravenous Nefopam, Dexmedetomidine, and Meperidine in Preventing Post-Spinal Anesthesia Shivering in Adult Patients Undergoing Lower Abdominal and Lower Limb Surgeries.
Egypt240 participantsStarted 2025-01-10
Plain-language summary
This prospective, randomized, controlled, double-blinded study is designed to evaluate the efficacy of nefopam compared to dexmedetomidine and meperidine for the prevention of postspinal anesthesia shivering while minimizing side effects.
Who can participate
Age range21 Years – 60 Years
SexALL
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Inclusion Criteria:
* Adult patients aged 21-60 undergoing elective lower abdominal, urological, gynecological, lower limb, orthopedic, or plastic surgeries under spinal anesthesia.
* ASA physical status I and II.
Exclusion Criteria:
* • Known hypersensitivity to nefopam, dexmedetomidine, or pethidine.
* Thyroid disorders, psychiatric disorders, severe diabetes, or autonomic neuropathies
* Known history of substance or alcohol abuse
* A history of convulsive disorders or severe neurological diseases
* Severe cardiac, pulmonary, renal, or hepatic disease
* Obstetric procedures and procedures requiring transfusion of blood and blood products.
* A contraindication to spinal anesthesia, e.g., coagulation disorders, local or general infection, increased intracranial tension, and progressive neurological disorders.
* Failed or partial spinal block.
What they're measuring
1
the incidence of shivering during the whole observation period