Influence of Fast and Slow Imagined Muscle Contractions on Muscle Function or Central Nervous Sys… (NCT06627491) | Clinical Trial Compass
RecruitingNot Applicable
Influence of Fast and Slow Imagined Muscle Contractions on Muscle Function or Central Nervous System Properties
United States18 participantsStarted 2024-10
Plain-language summary
The goal of this randomized clinical trial is to learn if imagining fast or slow muscle contractions causes different responses for nervous system excitability and muscle function in young, healthy males and females in. The main questions are:
Does imagining fast muscle contractions cause greater nervous system excitability compared to imagining slow muscle contractions?
Does imagining fast muscle contractions increase muscle function compared to imagining slow muscle contractions?
A control condition (rest) will be compared with two intervention conditions: imagining fast and imagining slow conditions, to determine if the fast and slow increase outcomes more than control and if fast has the greatest response.
Participants will:
* Attend 4 laboratory visits
* Perform 50 imagined contractions fast or slow, but with no physical movement
* Physical muscle contractions and non-invasive brain stimulation would be completed before and after each condition.
Who can participate
Age range
18 Years – 30 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Be between the ages of 18 - 30
* Healthy (no medical conditions)
* If female, must be taking the same monophasic oral contraceptive for the past 6 months
* Have a body mass index between 18.5 - 30 kg/m2
* Have not performed structured cardiovascular or resistance exercise in past 3 years
* Be right-handed
* Not currently taking stimulants, antipsychotic, anxiety, or depression medications
* Have not suffered an upper extremity musculoskeletal injury within the past year
Exclusion Criteria:
* If transcranial magnetic stimulation (TMS) is not deemed appropriate depending on your responses to the TMS-specific questionnaire
* Being ambidextrous
* Although rare, you will be excluded if discernable muscle activation responses are not possible via TMS
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in rate of torque development as measured by newton-meters per second
Timeframe: Baseline, minute 20
2
Change in nervous system excitability as measured by electromyographic waveform aplitude following motor cortex stimulation