Lipoprotein (a) and Vascular Regenerative Cell Content
Canada40 participantsStarted 2024-10-05
Plain-language summary
Lp(a)-VRCE is an observational, cross sectional study looking at vessel reparative stem cell content in people with and without elevated lipoprotein (a) \[Lp(a)\]. Specifically, the type and number of these cells in peripheral blood samples will be measured in participants with Lp(a) ≥100 nmol/L and compared to participants with Lp(a) \< 100 nmol/L. Determining the presence or absence of specific cells with blood vessel repair capacity in participants with high Lp(a) will further our knowledge of potential mechanisms through which Lp(a) influences cardiovascular health.
Who can participate
Age range18 Years – 80 Years
SexALL
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Inclusion criteria
✓. Adults ≥18 years of age and ≤80 years of age who meet either of the following criteria:
✓. Elevated Lp(a) (defined as greater than or equal to 100 nmol/L)
✓. Non-elevated Lp(a) (defined as less than 100 nmol/L)
✓. Willing and able to provide written informed consent and comply with study procedures.
Exclusion criteria
✕. Unable or unwilling to provide written informed consent or provide a peripheral blood sample.
✕. Any life-threatening disease expected to result in death within two years of consent.
✕. Any malignancy not considered cured (except basal cell carcinoma of the skin). An individual is considered cured if there has been no evidence of cancer recurrence for the five years prior to screening.
✕. Uncontrolled hypertension.
✕. New York Heart Association Class IV heart failure.
What they're measuring
1
Difference in the frequency or absolute number of circulating ALDHhiSSClo primitive myeloid progenitor cells between individuals with elevated Lp(a) and individuals with non-elevated Lp(a)
Timeframe: Baseline
Trial details
NCT IDNCT06626659
SponsorCanadian Medical and Surgical Knowledge Translation Research Group