CD7 CAR T Cells (RD13-02) in the Treatment of Relapsed/Refractory Severe Aplastic Anemia

Exclusion criteria

• ✕. Echocardiogram showing left ventricular ejection fraction (LVEF) \<45% (assessed during screening).
• ✕. History of any serious arrhythmia, currently on treatment for arrhythmias, significant history of myocardial infarction, clinically significant valvular heart disease (including mild or greater aortic regurgitation or moderate or greater mitral regurgitation), recurrent syncope, or significant hypercoagulable vascular events (e.g., transient ischemic attack or stroke); history of pulmonary embolism.
• ✕. Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) ≥2.5× the upper limit of normal (ULN);
• ✕. Total bilirubin ≥1.5×ULN, except in subjects with Gilbert's syndrome.
• ✕. Pulmonary hypertension, including secondary pulmonary hypertension, classified as WHO functional class \>2.