An Open Label Dose Escalation Study to Assess the Safety, Tolerability, and Pharmacologic Propert… (NCT06614894) | Clinical Trial Compass
RecruitingPhase 2/3
An Open Label Dose Escalation Study to Assess the Safety, Tolerability, and Pharmacologic Properties of High Dose Ambroxol Hydrochloride in Adult (≥ 18 Years of Age) Subjects With MPS III
United States10 participantsStarted 2024-12-01
Plain-language summary
A dose escalation study to evaluate the safety, tolerability, and pharmacologic properties of Ambroxol in adult participants with Sanfilippo disease(s) (MPS3).
Who can participate
Age range18 Years – 99 Years
SexALL
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Inclusion criteria
✓. IRB - approved informed consent/assent signed by subject and/or parent(s) or legal guardian(s).
✓. Genetically confirmed diagnosis of MPS III disease.
✓. Genomic DNA analysis demonstrating a homozygous or compound heterozygous pathogenic variants in SGSH (type A), NAGLU (type B), HGSNAT (type C), or GNS (type D) genes. Type E will not be studied.
✓. Elevated excretion of urinary GAGs and/or serum HS (if no historical data is available, screening GAGs and serum HS values will be utilized to assess inclusion criteria).
✓. Male or female; eighteen years of age and older, who is able to take Ambroxol Hydrochloride orally.
✓. Negative urine pregnancy test at screening for female subjects with child-bearing potential.
✓. The subject is willing to abstain from consumption of grapefruit, grapefruit juice, or grapefruit containing products for 72 hours prior to administration of the first dose of Ambroxol and for the duration of the treatment period.
Exclusion criteria
✕. Unwilling or unable to follow protocol requirements as per principal investigator.
✕. Any serious or chronic medical illness, including significant cardiac or severe debilitating pulmonary disease.
✕. Poorly controlled seizures, defined as more than one seizure per day for the past 6 months.
. Medications identified as a strong inducers or inhibitors of CYP3A, and changing to another alternative drug to treat the condition would place the subject at undue risk.
✕. Any medical condition that, in the opinion of the PI, would make the subject unsuitable to participate in the study.
✕. Inability to cooperate for clinical and safety data collection.
✕. Known hypersensitivity to Ambroxol or any of its excipients.
✕. Use of genistein or Miglustat within one week of starting screening.