RecruitingNot Applicable

Assessments of Adipogenesis, Lipid Turnover and Cellular Composition in Adipose Tissue in Response to Endurance Exercise

United States70 participantsStarted 2024-09-11

Plain-language summary

The purpose of this research study is to study the effects of endurance exercise training on adipose (fat) tissue quality and insulin sensitivity in men and women.

Who can participate

Age range18 Years – 45 Years

SexALL

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Inclusion criteria

✓. Men and pre-menopausal women;
✓. 18-45 years of age;
✓. BMI 30.0-40.0 kg/m2;
✓. For women, if not using pharmaceutical (hormonal) contraception (i.e. birth control pills, vaginal ring, injections, or implant), must agree to use either a double barrier method as a form of birth control to prevent pregnancy (i.e. male condom with spermicide, with or without cervical cap or diaphragm); use implants or intrauterine contraceptive devices; have a tubal ligation (surgically sterile); practice abstinence; or be in an established relationship with a vasectomized or same sex partner during the entire duration of the study;
✓. Able to speak and understand written and spoken English;
✓. Sedentary defined as self-reporting no more than 1 day per week, lasting no more than 60 minutes, of regular (structured) endurance or resistance exercise in the past year.
✓. Must be willing to be randomized to either study group;
✓. Must be willing to adhere to all study procedures.

Exclusion criteria

✕. Self-reported unstable body weight in the last 3 months (\> ±5%);
✕. Significant changes in the quality of the diet or the level of physical activity within the last 3 months;
✕. Weight \>396 lb (180 kg);
✕. Diagnosis of Type 1 or Type 2 diabetes mellitus;
✕. Fasting blood glucose ≥126 mg/dL;
✕. HbA1c ≥ 6.5%
✕. Blood pressure \>140/90 mmHg ;
✕. Self-reported history or presence of the following cardiovascular conditions: congestive heart failure, coronary artery disease, significant valvular disease, congenital heart disease, serious arrhythmia, stroke, symptomatic peripheral artery disease, stable angina, myocardial infarction or coronary revascularization within 6 months; clinically significant abnormalities on ECG, presence of cardiac pacemaker, or implanted cardiac defibrillator; inability to complete the VO2max test;

What they're measuring

In vivo adipogenesis

Timeframe: Before and following 12 weeks of deuterium (2H) labelled water administration and either endurance exercise training or control (no exercise)

Trial details

NCT IDNCT06602141

SponsorAdventHealth Translational Research Institute

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2029-04

Contact for this trial

Recruitment Department

407-303-7100 CFD.TRI.Recruitment@AdventHealth.com

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