RecruitingNot Applicable

The Effect of Acute Exogenous Oral Ketone Supplementation on Immune Cells Function and Immune Cells Histone Β-hydroxybutyrylation

Canada12 participantsStarted 2024-10-01

Plain-language summary

To conduct a single-arm pilot study to determine how acute ingestion of an exogenous ketone monoester supplement alters the histone lysine β-hydroxybutyrylation and immune function in healthy human monocytes and lymphocytes.

Who can participate

Age range19 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Over the age of 19 * Able to fast overnight Exclusion Criteria: * Being a competitive endurance athlete. * Following a ketogenic diet, low-calorie diet, periodic fasting regimen, or regularly consuming ketogenic supplements. * Being unable to travel to and from the university * Being pregnant. * Having been diagnosed with a chronic disorder of glucose or fat metabolism, including type 2 diabetes, chronic pancreatitis, or gallbladder disease * Being unable to read or communicate in English.

What they're measuring

β-hydroxybutyrylation of histone in human immune cells using Western blotting

Timeframe: Before (fasted state) and 2 hours after the consumption of the exogenous ketone supplement.

Trial details

NCT IDNCT06590623

SponsorUniversity of British Columbia

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-06-01

Contact for this trial

Jonathan Little Principal Investigator, Professor Little, Ph.D

250-807-9876 jonathan.little@ubc.ca

View on ClinicalTrials.gov More Ketosis, Metabolic trials