RecruitingNot Applicable

End-Tidal Oxygen for Intubation in the Emergency Department

United States, Australia1,400 participantsStarted 2024-08-05

Plain-language summary

Rapid Sequence Intubation (RSI) is a high-risk procedure in the emergency department (ED). Patients are routinely preoxygenated (given supplemental oxygen) prior to RSI to prevent hypoxia during intubation. For many years anaesthetists have used end-tidal oxygen (ETO2) levels to guide the effectiveness of preoxygenation prior to intubation. The ETO2 gives an objective measurement of preoxygenation efficacy. This is currently not available in most EDs. This trial evaluates the use of ETO2 on the rate of hypoxia during intubation for patients in the ED.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. The patient is located in the ED resuscitation bay of the participating centre.
✓. The planned procedure is orotracheal intubation using a laryngoscope and RSI technique with preoxygenation for patients who are spontaneously breathing.
✓. The patient is deemed to be at a high risk of hypoxia during RSI as per the treating ED clinician, as defined by:

Exclusion criteria

✕. Patient is known to be less than 18 years old.
✕. The patient has a supraglottic device in-situ e.g iGel or LMA.
✕. The patient is known to be pregnant.
✕. The patient is known to be a prisoner.
✕. The patient was intubated in the prehospital environment.
✕. Immediate need for tracheal intubation precludes preoxygenation i.e. the patient is in cardiac arrest.

What they're measuring

Incidence of hypoxia

Timeframe: The time when laryngoscope first enters the mouth to 2 minutes after the endotracheal tube [ETT] is confirmed on waveform capnography

Trial details

NCT IDNCT06578468

SponsorSydney Local Health District

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2025-12-31

Contact for this trial

Matthew Oliver, MBBS

+61410188680 matthew.oliver@health.nsw.gov.au

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