Implantation of Engineered Cartilage Grafts for Treatment of Patellofemoral Osteoarthritis Versus Surgical Comparators.

Inclusion Criteria: * Patient age is ≥18 and ≤ 70 years at time of screening. * Symptomatic PFOA grade 1-4 according to Iwano Classification * Chondropathy Grade 3-4 according to ICRS classification of the patella, trochlea femoris or both * Baseline score of \<75 on the KOOS-5 subjective knee evaluation. * Free range of motion of the affected knee joint or ≤ 5° of extension loss and minimum 125° flexion. * Patient is willing and able to give written informed consent to participate in the study and to comply with all study requirements, including attending all follow-up visits and assessments and to complete postoperative rehabilitation regimen. * Minimum values for women: Haemoglobin 120g/l, Platelets 150G/l, INR\<1.3 * Minimum values for men: Haemoglobin 140g/l, Platelets 150G/l, INR\<1.3 * Patients have failed to demonstrate adequate response to non-pharmacological interventions (e.g. structured land-based exercise programs) and pharmacological first-line treatment such as topical NSAIDs Exclusion Criteria: * Patient is the investigator or any sub-investigator, research assistant, pharmacist, study coordinator, other staff or relative thereof directly involved in the conduct of the protocol or in a dependency or employment with the sponsor. * Patient is unwilling, unable or lacking the capacity to provide informed consent * Patient is unable to undergo magnetic resonance imaging (MRI) * Prior surgical treatment of the target knee within 12 months (Note: prior diagnostic…