Anticholinergic Deprescription in Schizophrenia

Exclusion criteria

• . Serious anticholinergic side-effects (e.g., fever, blurred vision) indicative of a need for immediate removal of anticholinergics,
• . Serious neurologic or medical condition/treatment that impacts the brain and Neurodegenerative conditions such as Parkinson's, dementia, etc.; autoimmune conditions such as Multiple Sclerosis (MS) and lupus; as well as traumatic brain injury (TBI).
• . Significant risk of suicidal or homicidal behavior.
• . Cognitive or language limitations, or any other factor that would preclude subjects providing informed consent.
• . Contraindications for MR imaging (e.g., a pacemaker).
• . Current SCID-verified substance use disorder will be excluded to avoid the confounding impact of significant substance use comorbidity. Participants with a history of substance use disorder that is in early or full remission will be eligible, to enhance generalizability.
• . Patients concurrently treated with electroconvulsive therapy will be excluded because of its effects on cognition.
• . No history of psychotic illness and no active Axis I disorder as determined by clinical interview using the SCID-NP.