This study is evaluating whether an experimental treatment called GLPG5101 helps to treat non-Hodgkin lymphoma (NHL) and if it is safe to use. This study will be carried out in 2 phases: * The first phase is to see which doses of GLPG5101 work best with the least number of side effects. * In the second phase, participants will receive the selected dose(s) based on the results in the first phase.
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Phase 1: Number of participants with adverse events (AEs) and serious adverse events (SAEs)
Timeframe: 2 years
Phase 1: Number of participants with Dose-Limiting Toxicities (DLTs)
Timeframe: From first dose up to Day 28
Phase 2: Number of participants with objective response (OR) per the Lugano Classification or International Primary central nervous system lymphoma Collaborative Group (IPCG) criteria for PCNSL or per iwCLL (CLL [Cohort 8] and DLBCL-RT [Cohort 7] only)
Timeframe: 2 years