The Effect of Subclinical Dose of Ketamine on Early Postoperative Pain Sensitivity in Patients Un… (NCT06559280) | Clinical Trial Compass
CompletedEarly Phase 1
The Effect of Subclinical Dose of Ketamine on Early Postoperative Pain Sensitivity in Patients Undergoing Salpingectomy
China84 participantsStarted 2024-08-24
Plain-language summary
The experiment aims to explore the clinical effect of subclinical doses of ketamine on early postoperative pain sensitivity in ectopic pregnancy population.
Who can participate
Age range
18 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age\>18 years old
* BMI 18-30 kg/m2;
* American Society of Anesthesiologists (ASA) classification I and II
* The patient was diagnosed with ectopic pregnancy through ultrasound examination, and it was confirmed that there was no embryo or gestational sac in the uterus; The patient has indications for laparoscopic ectopic pregnancy surgery;
* All patients are scheduled to undergo laparoscopic salpingectomy for treatment Normal mental state;
* No cognitive impairment;
* Normal communication skills, no speech barriers
Exclusion Criteria:
* Individuals with severe organ dysfunction such as heart, lungs, liver, and kidneys;
* Individuals with serious mental illnesses;
* Long term use of sedatives and analgesics or long-term alcoholism and smoking;
* History of allergy to ketamine and related drugs
* There is a serious risk of hypertension or elevated intracranial pressure, as well as contraindications for the use of ketamine in cases of hyperthyroidism Refuse to join the trial;
* Patients with a history of other chronic pain diseases.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial used a subclinical dose of ketamine during salpingectomy for ectopic pregnancy — what does 'subclinical dose' mean in practice, and how does that differ from the amount of ketamine typically used in anesthesia?
2Since this was an early Phase 1 trial focused on postoperative pain sensitivity, what do the results actually tell us about whether low-dose ketamine reduces pain after this type of surgery, and is the evidence strong enough yet to influence my care?
3The trial is now completed — have the results been published or shared anywhere, and can you help me understand what they found about pain sensitivity after salpingectomy?
4If I need a salpingectomy for an ectopic pregnancy, would adding a low-dose ketamine approach to my anesthesia plan be something worth considering based on what this study found, or is it still too early to recommend it routinely?
5Are there any known risks or side effects associated with subclinical ketamine doses during surgery that I should weigh when thinking about whether this approach might be relevant to my treatment?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Postoperative pain sensitivity
Timeframe: Preoperative, one day after surgery, the second day after surgery, and one week after surgery