The Effect of Subclinical Dose of Ketamine on Early Postoperative Pain Sensitivity in Patients Un… (NCT06559280) | Clinical Trial Compass
CompletedEarly Phase 1
The Effect of Subclinical Dose of Ketamine on Early Postoperative Pain Sensitivity in Patients Undergoing Salpingectomy
China84 participantsStarted 2024-08-24
Plain-language summary
The experiment aims to explore the clinical effect of subclinical doses of ketamine on early postoperative pain sensitivity in ectopic pregnancy population.
Who can participate
Age range18 Years
SexFEMALE
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Inclusion Criteria:
* Age\>18 years old
* BMI 18-30 kg/m2;
* American Society of Anesthesiologists (ASA) classification I and II
* The patient was diagnosed with ectopic pregnancy through ultrasound examination, and it was confirmed that there was no embryo or gestational sac in the uterus; The patient has indications for laparoscopic ectopic pregnancy surgery;
* All patients are scheduled to undergo laparoscopic salpingectomy for treatment Normal mental state;
* No cognitive impairment;
* Normal communication skills, no speech barriers
Exclusion Criteria:
* Individuals with severe organ dysfunction such as heart, lungs, liver, and kidneys;
* Individuals with serious mental illnesses;
* Long term use of sedatives and analgesics or long-term alcoholism and smoking;
* History of allergy to ketamine and related drugs
* There is a serious risk of hypertension or elevated intracranial pressure, as well as contraindications for the use of ketamine in cases of hyperthyroidism Refuse to join the trial;
* Patients with a history of other chronic pain diseases.
What they're measuring
1
Postoperative pain sensitivity
Timeframe: Preoperative, one day after surgery, the second day after surgery, and one week after surgery