Topical 1% Methotrexate Gel Versus Clobetasol Propionate in Patients With Psoriasis (NCT06555497) | Clinical Trial Compass
CompletedEarly Phase 1
Topical 1% Methotrexate Gel Versus Clobetasol Propionate in Patients With Psoriasis
Philippines2 participantsStarted 2022-01-01
Plain-language summary
A pilot study on the formulation of topical methotrexate was conducted. Patients after baseline evaluation were randomly placed into either topical 1% methotrexate gel or clobetasol propionate 0.05% ointment which was applied for 6 weeks. PASI score was assessed at two-week intervals for a total of eight weeks. Blood chemistry parameters, whole abdomen ultrasound, and adverse drug reactions while on treatment and after eight weeks were monitored as secondary outcome measures.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* patients with stable mild-moderate plaque psoriasis, regardless of chronicity of the disease,
* involving less than 30% of the body surface area (BSA)
* negative pregnancy test for female participants of reproductive age
Exclusion Criteria:
* patients with psoriatic lesions on the face and/or scalp,
* administration of topical, systemic, or intralesional therapy or UV radiation therapy for at least 2 weeks before the study.
* Patients with deranged laboratory results at the baseline of the study, minors or lactating mothers
* patients planning a pregnancy with their spouses/partners in the next three months.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Psoriasis Area and Severity Index (PASI) score computed
Timeframe: 8 weeks
Trial details
NCT IDNCT06555497
SponsorDr. Jose N. Rodriguez Memorial Hospital and Sanitarium