Tryptophan Metabolism in Healthy Young Adults (NCT06551545) | Clinical Trial Compass
CompletedNot Applicable
Tryptophan Metabolism in Healthy Young Adults
Canada10 participantsStarted 2025-01-01
Plain-language summary
Tryptophan is an essential amino acid needed for growth and bodily functions. It is used to make serotonin which is needed for the brain to develop and function properly. However, when the body is stressed, tryptophan is broken down into compounds that can cause harm to the brain. Premature babies who get nutrition through their vein \[i.e. total parenteral nutrition (TPN)\] can experience this type of stress. The amount of tryptophan in TPN solutions is much higher than what premature babies need and can produce too much harmful compounds. So, it is important to study the amount of these compounds made from tryptophan. But there are no methods available to study this. Therefore, the goal of this study is to develop a method to measure the compounds made from tryptophan breakdown in adults so that it can be used for preterm babies on TPN later.
Who can participate
Age range18 Years – 45 Years
SexMALE
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Inclusion criteria
✓. Consent provided
✓. Aged 18 to 45 years old (inclusive)
✓. In good general health as evidenced by medical history, physical health and biochemistry
✓. Fasting blood glucose, hemoglobin A1c (HbA1c), urea, creatinine and CRP levels within normal ranges for age.
Exclusion criteria
✕. Presence of chronic disease and/or acute illness known to affect protein/amino acid metabolism (e.g. HIV, diabetes, cancer, liver or kidney disease, neurological conditions including depression and anxiety, hypo- / hyperthyroidism, inflammatory conditions,, anemia, acute cold or flu)
✕. Taking medications known to affect protein/AA metabolism (e.g. steroids, anti-inflammatory medications, acetaminophen, selective serotonin reuptake inhibitors (SSRI))
✕. Inability to tolerate the diet (i.e. allergy)
✕. Significant weight loss during the past month or consumption of weight reducing diets.
✕
What they're measuring
1
Fractional Synthesis Rate (FSR) of tryptophan metabolites