Effects of tES Combined With Retrieval Practice on Semantic Memory in Patients With Schizophrenia (NCT06547996) | Clinical Trial Compass
CompletedNot Applicable
Effects of tES Combined With Retrieval Practice on Semantic Memory in Patients With Schizophrenia
China72 participantsStarted 2024-08-30
Plain-language summary
The semantic processing deficit stands as a central feature of cognitive abnormalities in schizophrenia. Both transcranial electrical stimulation (tES) and retrieval practice have been demonstrated as external techniques capable of ameliorating the semantic processing deficit in individuals with schizophrenia. The inquiry examines whether the combined effect of tES and retrieval practice, following tES intervention targeting the left dorsolateral prefrontal cortex (L-DLPFC) in patients with schizophrenia, contributes to the preservation of semantic memory in these individuals.
Investigators plan to recruit 60 patients diagnosed with schizophrenia from hospitals. Treatment is administered by two examiners, each patient receives transcranial electrical stimulation（2mA×20min） with simultaneous learning of word lists. Each participant of each stimulation type was involved in both learning conditions, meaning that all participants completed both retrieval and restudy learning and testing Subsequently, Investigators observed their immediate and delayed memory performance through tests.
Who can participate
Age range18 Years – 60 Years
SexALL
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Inclusion criteria
✓. Meeting the diagnostic criteria for schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5);
✓. Aged 18 years or older, regardless of gender, with an educational level of elementary school or above;
✓. All patients received stable-level antipsychotic medication treatment, were in a stable phase of disease treatment, able to understand the testing requirements, and cooperated to complete all research tasks;
✓. No history of neurological disorders or other serious physical illnesses, and no history of intellectual disability;
✓. No color blindness, color weakness, or other color vision impairments, with normal vision or corrected vision.
Exclusion criteria
✕. Clear cognitive impairment caused by somatic or cerebral organic lesions, such as cerebrovascular diseases, traumatic brain injury, etc;
✕. Individuals with mental disorders caused by substance dependence or abuse, or the use of psychoactive substances;