A phase 1, randomized, double blind, placebo controlled drug-drug interaction, pharmacokinetics and safety study of cefiderocol in combination with xeruborbactam in healthy adult participants
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The incidence and nature of treatment emergent adverse events (TEAE)
Timeframe: up to day 17 or up to day 21
Number of patients with changes from baseline in safety parameters
Timeframe: up to day 17 or up to day 21
Maximum plasma concentration (Cmax)
Timeframe: up to day 17 or up to day 21
Time to maximum plasma concentration (Tmax)
Timeframe: up to day 17 or up to day 21
Area under the plasma concentration versus time curve (AUC)
Timeframe: up to day 17 or up to day 21
Terminal elimination half-life (t1/2,z)
Timeframe: up to day 17 or up to day 21
Terminal elimination rate constant (λz)
Timeframe: up to day 17 or up to day 21
Total clearance (CL)
Timeframe: up to day 17 or up to day 21
Renal clearance (CLR)
Timeframe: up to day 17 or up to day 21
Fraction of dose excreted in urine (Feu)
Timeframe: up to day 17 or up to day 21