This study will be conducted in order to determine the effect of repeated oral doses of camizestrant on the pharmacokinetics (PK) of midazolam and to determine the effect of repeated oral titrated doses of carbamazepine on the PK of camizestrant in healthy post-menopausal female participants.
Age range
50 Years – 70 Years
Sex
FEMALE
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Part A: Area under concentration-time curve from time 0 to infinity (AUCinf) of midazolam
Timeframe: Period 1 (Day 1) and Period 3 (Day 7 to Day 8)
Part A: Area under concentrationcurve from time 0 to the last quantifiable concentration (AUClast) of midazolam
Timeframe: Period 1 (Day 1) and Period 3 (Day 7 to Day 8)
Part A: Maximum observed plasma (peak) drug concentration (Cmax) of midazolam
Timeframe: Period 1 (Day 1) and Period 3 (Day 7 to Day 8)
Part B: Area under concentration-time curve from time 0 to infinity (AUCinf) of camizestrant
Timeframe: Period 1 (Day 1 to Day 4), Period 2 (Day 22 to Day 25)
Part B: Area under concentrationcurve from time 0 to the last quantifiable concentration (AUClast) of camizestrant
Timeframe: Period 1 (Day 1 to Day 4), Period 2 (Day 22 to Day 25)
Part B: Maximum observed plasma (peak) drug concentration (Cmax) of camizestrant
Timeframe: Period 1 (Day 1 to Day 4), Period 2 (Day 22 to Day 25)