CompletedNot Applicable

1% Lidocaine Paracervical Block for Endometrial Biopsy

Canada96 participantsStarted 2025-06-19

Plain-language summary

The objective of this study is to to determine whether 1% lidocaine paracervical block reduces pain during endometrial biopsy in comparison to no intervention. The proposed study is a double-blind randomized controlled trial (RCT). Each participant will be randomly assigned to one of two arms: 1. intervention (paracervical block - 10 mL 1% lidocaine with epinephrine) 2. control (gently tapping the cervicovaginal junction with a capped needle) The primary outcome will be a global pain score, which will be patient-reported by the 100 mm Visual Analogue Scale (VAS) following the procedure.

Who can participate

Age range18 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria * Any participant \> or = age 18 years old presenting for an endometrial biopsy * All parities of patients are eligible * English speaking participants only Exclusion Criteria * Use of pain medication that is not an NSAID or acetaminophen (e.g. opioids, benzos) within past 24 hours * Confirmed pregnancy * Any diagnosed chronic pain syndromes (eg. fibromyalgia, vaginismus, interstitial cystitis) * Contraindication to lidocaine * Misoprostol administration within 24 hours * Previous unsuccessful office attempt at endometrial biopsy by the same practitioner (note of clarification: previous unsuccessful biopsy attempt by a different practitioner will still be eligible)

What they're measuring

Global pain score

Timeframe: Immediately after the completion of the procedure

Trial details

NCT IDNCT06546254

SponsorMount Sinai Hospital, Canada

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-01-22

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