Azithromycin Before Induction (NCT06543290) | Clinical Trial Compass
RecruitingPhase 1
Azithromycin Before Induction
United States400 participantsStarted 2023-08-07
Plain-language summary
This is a double blinded randomized control trial involving administration of 2 grams prophylactic azithromycin in third trimester patients undergoing induction of labor at our institution to demonstrate reduction in maternal and neonatal infection.
Who can participate
Age range18 Years – 45 Years
SexFEMALE
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* • Third trimester of pregnancy defined as 28 0/7 weeks or more
* Singleton pregnancy
* Age 18-45
* Induction of labor initiated for medical or obstetrical reason or electively over 39 weeks of gestation
* No contraindication to vaginal delivery
* Reassuring fetal heart rate tracing
* Able and willing to provide informed consent
Exclusion Criteria:
* • Does not read or write in English or Spanish
* Unable or unwilling to give informed consent
* Use of antibiotic or antiviral agent within the last 7 days
* Evidence of active infection at the time of initiation of induction (patients with rectovaginal group B streptococcus positive results will be allowed to participate as it is a colonizing organism, unless they show evidence of active infection)
* Incarcerated Women
* Active substance abuse
* Age \< 18