The purpose of this study is to evaluate the safety and feasibility of transcutaneous auricular Vagus Nerve Stimulation (taVNS) paired with upper-limb rehabilitation in adults with tetraplegia caused by cervical spinal cord injury.
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Safety as assessed by number of subjects with change in systolic blood pressure
Timeframe: Immediately after completing in-clinic 18 sessions (6-8 weeks)
Safety as assessed by number of subjects with change in diastolic blood pressure
Timeframe: Immediately after completing in-clinic 18 sessions (6-8 weeks)
Safety as assessed by number of subjects with change in heart rate
Timeframe: Immediately after completing in-clinic 18 sessions (6-8 weeks)
Safety as assessed by number of subjects with change in respiratory rate
Timeframe: Immediately after completing in-clinic 18 sessions (6-8 weeks)
Safety as assessed by number of subjects with change in autonomic dysreflexia
Timeframe: Immediately after completing in-clinic 18 sessions (6-8 weeks)
Safety as assessed by number of subjects with worsening spasticity
Timeframe: Immediately after completing in-clinic 18 sessions (6-8 weeks)
Safety as assessed by number of subjects with change in pain at stimulation site
Timeframe: Immediately after completing in-clinic 18 sessions (6-8 weeks)
Safety as assessed by number of adverse events that occurred during the study period
Timeframe: post therapy 30 days
Feasibility as assessed by the number of treatment sessions attended by each participant . The intervention is considered feasible if at least 80% adherence rate is achieved and no serious adverse events occurred.
Timeframe: from baseline through completion of 18 sessions (about 6-8 weeks)
Feasibility as assessed by the participants' perceptions of the study procedures
Timeframe: from baseline through completion of 18 sessions (about 6-8 weeks)
Feasibility as assessed by the participants' perceptions of the usefulness of the intervention
Timeframe: from baseline through completion of 18 sessions (about 6-8 weeks)