Treatment of Moderate to Severe Plaque Psoriasis

Exclusion criteria

• ✕. Active hepatitis, or hepatitis B surface antigen (HBsAg) positive, or hepatitis B core antibody (HBcA positive and Hepatitis B virus (HBV) DNA positive, or Hepatitis C virus (HCV) antibody positive and HCV-RNA positive;
• ✕. Positive for HIV antibody during the screening period, or have a history of HIV infection in the past;
• ✕. Positive Treponema pallidum antibody and positive non-Treponema pallidum serum test (RPR or TRUST) during the screening period;
• ✕. Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ≥ 3 times upper limit of normal (ULN);
• ✕. Hemoglobin \<90g/L;
• ✕. White blood cell count\< 3.0×109/L;
• ✕. Neutrophil count\<1.0×109/L;
• ✕. Lymphocyte count\<0.5×109/L;