A New Strategy for Preoperative Drainage of Resectable Pancreatic Head Cancer Combined Severe Obs… (NCT06541340) | Clinical Trial Compass
RecruitingNot Applicable
A New Strategy for Preoperative Drainage of Resectable Pancreatic Head Cancer Combined Severe Obstructive Jaundice
China360 participantsStarted 2024-08-01
Plain-language summary
Severe obstructive jaundice caused by pancreatic head cancer usually requires preoperative biliary drainage, but its necessity and effectiveness are controversial, and specific strategies lack clear standards. This study proposed a new strategy for preoperative biliary drainage using serum prealbumin as the main evaluation index, and compared it with the traditional strategy using serum total bilirubin as the main evaluation index. Through a randomized, controlled, multicenter prospective study, we explored the effects of different drainage strategies on the incidence of in-hospital complications and long-term prognosis of patients with resectable pancreatic head cancer, guided clinical decisions on preoperative drainage time and surgical timing, and provided high-quality evidence-based medicine for preoperative biliary drainage of pancreatic head cancer.
Who can participate
Age range18 Years – 75 Years
SexALL
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Inclusion criteria
✓. Pathological diagnosis of pancreatic head cancer, or clinical diagnosis of pancreatic head cancer after multidisciplinary discussion, clear presence of obstructive jaundice caused by pancreatic head tumor, and planned to undergo radical pancreaticoduodenectomy
✓. Preoperative imaging stage is resectable
✓. Baseline serum total bilirubin ≥ 250μmol/L, and no history of preoperative biliary drainage