The purpose of this first-in-human study is to evaluate the safety and tolerability of INT2104 when administered to humans in a broad population of participants with refractory/relapsing B-cell malignancies. Preliminary efficacy information may also be obtained. INT2104 is a gene therapy delivering a transgene for a chimeric antigen receptor (CAR) specific for CD20 (CAR20). The lentiviral vector is designed to generate CAR T and CAR Natural Killer (NK) cells inside the body following intravenous (IV) administration. Study details include the following: * The study duration will be 5 years * The treatment duration will be a one-time intravenous (IV) infusion of INT2104
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Number of Participants With Treatment-emergent Adverse Events
Timeframe: Up to 5 years
Number of Participants With Abnormal Clinical Laboratory Values and Physical Examination Results
Timeframe: Baseline, up to Day 29
Number of Participants Experiencing Cytokine Release Syndrome (CRS)
Timeframe: Baseline, up to Day 29
Number of Participants Experiencing Immune Effector Cell Neurotoxicity (ICANS)
Timeframe: 28 Days
Number of Participants Experiencing dose-limiting toxicities (DLTs)
Timeframe: 28 Days